兩年前,治療糖尿病和肥胖癥的GLP-1藥物一經問世,患者們便爭相購買。包括司美格魯肽注射液諾和泰(Ozempic)、威哥維、Mounjaro(Tirzepatide,替西帕肽)和Zepbound(Tirzepatide,替西帕肽)在內的GLP-1藥物如此受歡迎,以至于沒過多久就出現了供不應求的局面。根據KFF Health Tracking最近進行的一項調查,現在有多達八分之一的成年人服用過GLP-1。
對GLP-1藥物的需求絲毫沒有放緩的跡象,因此,假冒GLP-1藥物越來越多,以至于世界衛生組織(WHO)上周發出警告,提醒人們注意假冒藥品。在發出警告的同時,制藥商禮來(Eli Lily)和諾和諾德(Novo Nordisk)還對幾家實體提起訴訟,要求停止銷售假藥。
馬薩諸塞州Integrated Gastroenterology Consultants的蘇普里亞·拉奧(Supriya Rao)博士說:“由于需求如此之高,以至于這些藥物一上市,藥店就開始斷貨。因此,醫療療養中心和調配藥房開始為患者填補這一空白。”
調配藥房使用基本成分調配藥物,而不是配發像司美格魯肽注射液諾和泰和威哥維這樣的知名品牌藥物。醫療療養中心、許多在線渠道和調配藥房不受美國食品藥品監督管理局(FDA)監管,因此患者從這些渠道獲得的藥物沒有任何保障。Omada Health首席醫療官卡羅琳·雅西克(Carolyn Jasik)博士解釋說:“復方藥物本質上是現有藥物的‘復制品’,但由于這些復方藥物未經美國食品藥品監督管理局批準,因此不具備與已批準藥物相同的安全性、質量和有效性保證。”
同樣,假藥(比如你可能在醫療療養中心或網上找到的)也不受監管。雅西克表示:“無論是什么假藥,都是危險的,會導致嚴重的健康后果。這些藥物可能劑量過大、包含錯誤成分或根本不含活性成分。簡而言之,你花錢購買的藥物要么會對你造成傷害,要么根本起不到任何作用。”
使用未受監管的GLP-1藥物可能面臨一些風險,包括惡心、腹瀉、血糖不規律、注射部位感染等。
通常情況下,患者之所以會選擇這些替代藥物,不僅是因為原研藥供應短缺,還因為它們的價格高得令人望而卻步。
雅西克說:“司美格魯肽(Semaglutide)藥物既有價值又有療效,但我們目前正陷入供應鏈和成本的困境,這使得大部分公眾無法獲得這些藥物。重要的是要注意到,這在很大程度上是導致假藥發展的首要原因。作為一名醫療服務提供者,我感到遺憾的是,這種救命藥物如此難以獲得,而且還出現了利用人們的愿望和醫療需求的假藥。”
關鍵信息:買家要當心。
如何避免買到假冒司美格魯肽注射液諾和泰和威哥維和其他GLP-1藥物
只在國家許可的藥店購買
盡管市場上的廉價替代品可能很誘人,或是僅為了獲得GLP-1藥物,但專家建議避免購買替代品。First Databank Inc.臨床藥劑師、藥學博士西蒙娜·多夫(Simona Dorf)說:“消費者應從國家許可的藥店或美國食品藥品監督管理局注冊的外包機構購買藥物,以最大限度地降低買到假冒產品的風險。必須核實持證醫療保健提供者的處方,避免使用未經核實的在線渠道或社交媒體網紅推薦的藥物。”
在網上購買任何藥物時都要自己進行研究
美國食品藥品監督管理局的BeSafeRx網站是可靠信息的良好來源,可以在點擊“購買”之前進行自我學習。該網站對冒充網上藥店的網站發出警告,建議消費者只從國家許可的網上藥店購買處方藥,并提供查找藥店位置的定位工具。此外,該網站還建議與醫生討論網上購買的任何藥物。
檢查包裝和標簽
標簽上的拼寫錯誤或印刷質量差是假藥的明顯標志。仔細檢查每個標簽,確保其真實性。除了這些危險信號之外,其他的危險信號還包括藥品名稱缺字或多字。你還可以在美國食品藥品監督管理局的網站上查詢序列號和批號。
避免在調配藥房購買
拉奧還提醒消費者,服用的任何藥物都有可能產生副作用。如果你不是從可信賴的渠道購買藥物,這些風險只會增加。她說:“調配藥房可能會導致滑坡效應,這取決于藥物的來源,誰知道你每天買到的是什么。注射來源不明的藥物是有風險的。”
雅西克說,無論是否服用GLP-1藥物,減肥還需要采取其他重要步驟。這些步驟包括持續的自我監測,如稱體重;保持均衡飲食;進行鍛煉以實現瘦體重;以及制定生活方式計劃以創建結構化方法。
無論你是否選擇服用減肥藥,保證安全都應該是你的首要任務。如果藥物是其中的一部分,那更應如此。多夫說:“與醫療保健提供者反復核對這些信息是至關重要的。認識到與假冒GLP-1藥物相關的風險并采取積極主動的措施,可以極大地保護消費者。隨著對這些藥物的需求持續增長,消費者和監管機構都必須提高警惕,以確保治療糖尿病和肥胖癥的安全性和有效性。”(財富中文網)
譯者:中慧言-王芳
兩年前,治療糖尿病和肥胖癥的GLP-1藥物一經問世,患者們便爭相購買。包括司美格魯肽注射液諾和泰(Ozempic)、威哥維、Mounjaro(Tirzepatide,替西帕肽)和Zepbound(Tirzepatide,替西帕肽)在內的GLP-1藥物如此受歡迎,以至于沒過多久就出現了供不應求的局面。根據KFF Health Tracking最近進行的一項調查,現在有多達八分之一的成年人服用過GLP-1。
對GLP-1藥物的需求絲毫沒有放緩的跡象,因此,假冒GLP-1藥物越來越多,以至于世界衛生組織(WHO)上周發出警告,提醒人們注意假冒藥品。在發出警告的同時,制藥商禮來(Eli Lily)和諾和諾德(Novo Nordisk)還對幾家實體提起訴訟,要求停止銷售假藥。
馬薩諸塞州Integrated Gastroenterology Consultants的蘇普里亞·拉奧(Supriya Rao)博士說:“由于需求如此之高,以至于這些藥物一上市,藥店就開始斷貨。因此,醫療療養中心和調配藥房開始為患者填補這一空白。”
調配藥房使用基本成分調配藥物,而不是配發像司美格魯肽注射液諾和泰和威哥維這樣的知名品牌藥物。醫療療養中心、許多在線渠道和調配藥房不受美國食品藥品監督管理局(FDA)監管,因此患者從這些渠道獲得的藥物沒有任何保障。Omada Health首席醫療官卡羅琳·雅西克(Carolyn Jasik)博士解釋說:“復方藥物本質上是現有藥物的‘復制品’,但由于這些復方藥物未經美國食品藥品監督管理局批準,因此不具備與已批準藥物相同的安全性、質量和有效性保證。”
同樣,假藥(比如你可能在醫療療養中心或網上找到的)也不受監管。雅西克表示:“無論是什么假藥,都是危險的,會導致嚴重的健康后果。這些藥物可能劑量過大、包含錯誤成分或根本不含活性成分。簡而言之,你花錢購買的藥物要么會對你造成傷害,要么根本起不到任何作用。”
使用未受監管的GLP-1藥物可能面臨一些風險,包括惡心、腹瀉、血糖不規律、注射部位感染等。
通常情況下,患者之所以會選擇這些替代藥物,不僅是因為原研藥供應短缺,還因為它們的價格高得令人望而卻步。
雅西克說:“司美格魯肽(Semaglutide)藥物既有價值又有療效,但我們目前正陷入供應鏈和成本的困境,這使得大部分公眾無法獲得這些藥物。重要的是要注意到,這在很大程度上是導致假藥發展的首要原因。作為一名醫療服務提供者,我感到遺憾的是,這種救命藥物如此難以獲得,而且還出現了利用人們的愿望和醫療需求的假藥。”
關鍵信息:買家要當心。
如何避免買到假冒司美格魯肽注射液諾和泰和威哥維和其他GLP-1藥物
只在國家許可的藥店購買
盡管市場上的廉價替代品可能很誘人,或是僅為了獲得GLP-1藥物,但專家建議避免購買替代品。First Databank Inc.臨床藥劑師、藥學博士西蒙娜·多夫(Simona Dorf)說:“消費者應從國家許可的藥店或美國食品藥品監督管理局注冊的外包機構購買藥物,以最大限度地降低買到假冒產品的風險。必須核實持證醫療保健提供者的處方,避免使用未經核實的在線渠道或社交媒體網紅推薦的藥物。”
在網上購買任何藥物時都要自己進行研究
美國食品藥品監督管理局的BeSafeRx網站是可靠信息的良好來源,可以在點擊“購買”之前進行自我學習。該網站對冒充網上藥店的網站發出警告,建議消費者只從國家許可的網上藥店購買處方藥,并提供查找藥店位置的定位工具。此外,該網站還建議與醫生討論網上購買的任何藥物。
檢查包裝和標簽
標簽上的拼寫錯誤或印刷質量差是假藥的明顯標志。仔細檢查每個標簽,確保其真實性。除了這些危險信號之外,其他的危險信號還包括藥品名稱缺字或多字。你還可以在美國食品藥品監督管理局的網站上查詢序列號和批號。
避免在調配藥房購買
拉奧還提醒消費者,服用的任何藥物都有可能產生副作用。如果你不是從可信賴的渠道購買藥物,這些風險只會增加。她說:“調配藥房可能會導致滑坡效應,這取決于藥物的來源,誰知道你每天買到的是什么。注射來源不明的藥物是有風險的。”
雅西克說,無論是否服用GLP-1藥物,減肥還需要采取其他重要步驟。這些步驟包括持續的自我監測,如稱體重;保持均衡飲食;進行鍛煉以實現瘦體重;以及制定生活方式計劃以創建結構化方法。
無論你是否選擇服用減肥藥,保證安全都應該是你的首要任務。如果藥物是其中的一部分,那更應如此。多夫說:“與醫療保健提供者反復核對這些信息是至關重要的。認識到與假冒GLP-1藥物相關的風險并采取積極主動的措施,可以極大地保護消費者。隨著對這些藥物的需求持續增長,消費者和監管機構都必須提高警惕,以確保治療糖尿病和肥胖癥的安全性和有效性。”(財富中文網)
譯者:中慧言-王芳
When GLP-1 drugs for diabetes and weight loss, exploded onto the scene two years ago, patients scrambled to get their hands on them. GLP-1s, which include Ozempic, Wegovy, Mounjaro and Zepbound, are so popular that it didn’t take long for them to wind up in short supply. According to one recent survey conducted by KFF Health Tracking, as many as one in eight adults has now used a GLP-1.
The demand shows no signs of slowing down, and as a result, counterfeit GLP-1 drugs are becoming an increasingly bigger piece of the landscape—so big in fact, that the World Health Organization (WHO) last week issued a warning to people to be wary of the fake versions. Alongside the warning, drug makers Eli Lily and Novo Nordisk have filed lawsuits against several entities to stop selling the counterfeits.
“As soon as these drugs hit the market, the demand was so high that pharmacies began running out of them,” says Dr. Supriya Rao of Integrated Gastroenterology Consultants in Mass. “So med spas and compounding pharmacies began filling that gap for patients.”
A compounding pharmacy creates medicines using base ingredients, rather than dispensing the name-brand medications like Ozempic and Wegovy. Med spas, many online sources, and compounding pharmacies do not fall under the umbrella of FDA regulation, so there are no safeguards on what a patient might receive from one of these sources. “Compounded medications are essentially ‘copies’ of available medications, but they do not have the same safety, quality, and effectiveness assurances as approved drugs since these compounded versions lack FDA approval,” explains Dr. Carolyn Jasik, chief medical officer for Omada Health.
Likewise, counterfeit drugs—like what you might find at a med spa or from an online source—are unregulated. “Counterfeit drugs, no matter what, are dangerous and can lead to serious health consequences,” says Jasik. “These medications can contain toxic doses, the wrong ingredients, or no active ingredients at all. In short, you’re paying for a drug that can either harm you or is doing nothing at all.”
Some of the risks you might face with an unregulated form of GLP-1 include nausea and diarrhea, irregular blood sugar levels, and infections at the sight of injection, among others.
Often, patients are drawn to these alternative sources not just because supply of the originals is short, but also because they can be prohibitively expensive.
“Semaglutide medications are valuable and effective, but we are currently caught in a moment where the supply chain and cost can make these drugs inaccessible to much of the broader public,” says Jasik. “It’s important to note that this is a large part of what drives the development of counterfeit drugs in the first place. As a medical provider, I’m sad that this lifesaving medication is so difficult to access and that it’s come to counterfeit drugs that take advantage of people’s desires and medical needs.”
The take-home message: buyer beware.
How to avoid fake Ozempic, Wegovy and other GLP-1s
Buy from state-licensed pharmacies only
As tempting as it might be to go for the cheaper alternatives on the market—or simply just to get your hands on a GLP-1 drug—the experts recommend steering clear. “Consumers should purchase medications from state-licensed pharmacies or FDA-registered outsourcing facilities to minimize the risk of counterfeit products,” says Simona Dorf, PharmD, and clinical pharmacist at First Databank Inc. “It’s essential to verify prescriptions from licensed healthcare providers and avoid drugs recommended by unverified online sources or social media influencers.”
Do your own research when purchasing any medication online
The FDA’s BeSafeRx website is a good source of credible information to educate yourself before hitting “buy.” The site warns against websites that pose as online pharmacies, and recommends consumers only buy prescription medicines from a state-licensed online pharmacy, plus offers a location tool to find one. Additionally, it recommends talking with your doctor about any meds you purchase online.
Check the packaging and labels
A sure sign that you’re dealing with a fake is misspellings on the label, or poor print quality. Give each label a good going over to make sure of its authenticity. Along with those red flags, others include a missing or added word to the drug’s name. You can also do a check on the serial numbers and lot numbers by checking the FDA’s website.
Avoid compounding pharmacies
Rao also reminds consumers that any medication you put in your body has the potential for side effects. Those risks only grow if you’re not purchasing them from trusted sources. “Compounding pharmacies can be a slippery slope,” she says. “Depending on who is sourcing the medication, who knows what you’re getting from one day to the next. Injecting a drug from an unknown source is risky.”
There are also important steps to take with regard to weight-loss, whether you are using a GLP-1 medication or not, said Jasik. These include consistent self-monitoring, like weigh ins; maintaining a balanced diet; exercises to help build lean body mass; and lifestyle programming to create a structured approach.
Whether you choose to use a weight-loss medication or not, safety should be front and center to your approach. And if the medication is part of that, even more so. “It is crucial to cross-check such information with healthcare providers,” said Dorf. “Awareness of the risks associated with counterfeit GLP-1 drugs and taking proactive measures can significantly protect consumers. As demand for these medications continues to grow, vigilance from both consumers and regulatory bodies is essential to ensure safety and efficacy in treating diabetes and obesity.”